Extended Data Fig. 1: Single-cell transcriptional landscape of non-cardiomyocytes in heart failure during intermittent exposure to BET bromodomain inhibition.
From: A transcriptional switch governs fibroblast activation in heart disease
a, Venn diagram showing overlap of TAC-induced and JQ1-suppressed genes (log2[FC] > 0.5; adjusted P < 0.05; false-discovery rate-adjusted, Benjamini–Hochberg correction) between bulk RNA-seq from undissociated left ventricle tissue5 and extracted cardiomyocytes. b, Heat map showing the top-5 markers per cluster in the scRNA-seq data. Total cells, n = 35,551 in 9 clusters. c, UMAP plots showing cluster identity of all cells (n = 35,551) and expression of Dcn, Postn, Ctgf, Lyz2 and Fabp4. d, e, UMAP plot coloured by sample identity of myeloid (d, n = 7,986) and endothelial (e, n = 10,672) cells.
