Extended Data Fig. 8: A closed pore domain with one small fenestration.
From: Structure of human Cav2.2 channel blocked by the painkiller ziconotide
a, The pore domain is in a closed conformation. Four perpendicular side views of the pore domain are shown. S4–5II is pushed downward as a result of the sliding of S4II. b, Side walls that involve S6II are sealed without fenestration. Side views of the pore domain surface are shown. There is only one fenestration on the interface of repeats III and IV.
