Extended Data Fig. 4: Lipids resolved in the structures.
From: Structure of human Cav2.2 channel blocked by the painkiller ziconotide
a, A PIP2 molecule binds to VSDII in both structures. All the densities shown are contoured at 3σ. b, The densities for the resolved cholesterol (Cho) and CHS molecules in Cav2.2–ziconotide. c, Lipids resolved in the structure of Cav2.2–ziconotide. The α1 subunit are shown in two opposite side views. The numbering for cholesterol and CHS is consistent with that in b. Two phospholipids are also resolved and assigned as phosphatidylethanolamine (PE).
