Extended Data Fig. 1: Synthetic route of the CPM analogues.
From: A condensate-hardening drug blocks RSV replication in vivo
The detailed synthesis protocol is described in the Supplementary Methods. The IDs of the end products are A3M (A-ring, 3′-methoxy-cyclopamine; compound 4), A3E (A-ring, 3′-ethoxy-cyclopamine, compound 6) and A3P (A-ring, 3′-propoxy-cyclopamine, compound 8). The name of A3E (3′-ethoxy-cyclopamine) according to IUPAC nomenclature is 3S,3′R,3a′S,6aS,6bS,6′S,7a′R,9R,11aS,11bR-3-ethoxy-3′,6′,10,11b-tetramethyl-1,2,3,3a′,4,4′,5′,6,6a,6b,6′,7,7′,7a′,8,11,11a,11b-octadecahydro-3′H-spiro[benzo[a]fluorene-9,2′-furo[3,2-b]pyridine].
