Fig. 3: Pan-ancestry collapsing analysis.
From: Rare variant contribution to human disease in 281,104 UK Biobank exomes
a, b, The change in Phred scores between the pan-ancestry and European-only analyses for 46,769 binary associations (a) and 39,541 quantitative associations (b) stratified by chapter. For gene–phenotype associations that appear in multiple collapsing models, we display only those with the lowest P value. The green dots indicate associations that were not significant in the European analysis but were significant in the combined analysis. The orange dots represent associations that were originally significant in the European-only analysis but became not significant in the combined analysis. In both figures, the y axis is capped at ΔPhred = 40 (equivalent to a P value change of 0.0001).
