Extended Data Figure 11: HPDL-dependent CoQ10 biosynthesis pathway.
From: The polar oxy-metabolome reveals the 4-hydroxymandelate CoQ10 synthesis pathway
The canonical tyrosine catabolism, HPDL-dependent (red), and HPDL-independent (purple) CoQ10 biosynthetic pathways are shown as indicated. The HPDL-independent pathway was proposed from earlier studies in rats34. Dotted lines represent unknown pathway or transport steps. Potential intermediates and enzymes are proposed within the 4-HMA, HPDL-dependent and HPDL-independent pathways.
