Extended Data Fig. 4: Ribosome pausing in single cells under amino acid limitation.
From: Single-cell Ribo-seq reveals cell cycle-dependent translational pausing
a, Heat map of the log2 fold change of amino acid occupancy in the RPF active sites. b, Distribution of cells exhibiting ribosome pausing in clusters. The threshold used to distinguish pausing cells was calculated as the mean plus 4 standard deviations of the signal of the cells from the rich condition. c, Proportions of treatment type per cluster. d, Proportions of treated cells that show a pausing response per cluster. e, Gene set enrichment analysis28 on the Reactome Pathway database showing the top twenty categories based on marker genes for HEK 293T cell clusters. Categories associated with the cell cycle are highlighted in bold.
