Extended Data Fig. 7: Extrahelical binding sites for allosteric modulators of class A GPCRs.
From: Positive allosteric mechanisms of adenosine A1 receptor-mediated analgesia
The unique extrahelical binding pose of MIPS521 in the A1R (orange) compared to previously reported extrahelical allosteric binding pockets for class A GPCRs in P2Y1R (BPTU, red; PDB 4XNV), PAR2 (AZ3451, yellow; PDB 5NDZ), CB1 (ORG28569, green; 6KQI), GPR40 (AP8, cyan; PDB 5TZY), C5aR (NDT9513727, blue; PDB 5O9H), D1R (LY3154207, navy; PDB 7LJD), and β2AR (Compound-6FA, pink; PDB 6N48).
