Extended Data Fig. 8: Conservation of TG supradomains in ALK and LTK.
From: Structural basis of cytokine-mediated activation of ALK family receptors
a, Structurally annotated multiple sequence alignments of the TG and EGFL domains of ALK and LTK using the ESPripT server (http://espript.ibcp.fr/ESPript/ESPript/). Hs (Homo sapiens), Mm (Mus musculus), Gg (Gallus gallus) Xl (Xenopus laevis), Xt (Xenopus tropicalis) Dr (Danio rerio). Symbols indicate residues participating in the different interfaces according to the graphical legend. b, Bottom view of dimerized LTK (left) and ALK (right) in surface representation coloured according to residue conservation. The ALKAL binding sites are shown as an outline of ALKAL1 (green) and ALKAL2 (blue) are shown as dashed lines. Conservation analysis was performed using the Consurf server (https://consurf.tau.ac.il) based on an alignment of 248 vertebrate sequences for ALK and 225 for LTK by COBALT. c, Top view of dimerized LTK (left) and ALK (right) coloured according to sequence conservation levels.
