Extended Data Fig. 1: Phylogenetic analysis and evolution of ALK and LTK.
From: Structural basis of cytokine-mediated activation of ALK family receptors
a, Phylogenetic analysis of ALK (a). Multiple sequence alignment was performed with MAFFT 7 using the E-INS-I algorithm for refinement. The phylogenetic tree was visualized using Phyl.io tool as implemented in MAFFT. ALK is an evolutionarily ancient RTK in C. elegans and D. melanogaster, where it is activated by HEN-150 and Jeb51,52. b, Sequence alignment of ALK sequences focusing on the heparin binding motif. Positively charged residues are highlighted in blue. The multiple sequence alignment was performed with MAFFT 7 using the E-INS-I algorithm for refinement. c, Phylogenetic analysis of LTK performed as for ALK. In mammals the LTK ectodomain consists of the TG and EGF-like domains while other vertebrates contain the additional MAM-LDLa-MAM domains at the N-terminus.
