Extended Data Fig. 5: IgA secretion and elimination in the in vivo mIgA reconstitution model.
From: Parallelism of intestinal secretory IgA shapes functional microbial fitness
a,b,c IgA concentration measurements of secretion and elimination after i.v. injection by ELISA following injection of monomeric (n = 2 mice) or dimeric mIgA in unmanipulated wild-type C57BL/6 (n = 2 mice) and dimeric mIgA in C57BL/6 mice (n = 3) following bile duct ligation (BDL). Serial measurements from serum (a), bile (b) or faeces (c), individual data points are shown. d, Decay of mIgA in serum after injection of different dimeric mIgAs (n = 3 for each condition; \(\bar{x}\) ± s.d.). e, c.f.u. in colonic/faecal fractions of JM83 at 10.5 h after reconstitution with the indicated mIgA species (\(\bar{x}\) ± s.d., mSIgA4250 n = 6, mSIgA4308 n = 3 and mSIgAB8-030 n = 5 faecal samples from individual mice).
