Fig. 1: Structure of the neurofibromin homodimer.
From: The structure of neurofibromin isoform 2 reveals different functional states
a, Overview of the Nf1 dimer with one protomer yellow and one pink. Dimer interaction regions are green. b, Domain organization of Nf1-23a. N-HEAT/ARM and C-HEAT/ARM domains are grey, GRD light blue and the Sec14-PH domain yellow. Locations of the interdomain linkers, exon 23a insert and S-rich region are annotated. c, Composite density map (left) and ribbon model (right) of the Nf1-23a homodimer in double-auto-inhibited conformation, coloured as in b. d, Nf1 double-auto-inhibited, closed state (left) and open state (right). The boxed insert (bottom left) shows that, in auto-inhibited, closed conformation, Ras, docked from the crystal structure complex with GRD (PDB entry 6ob3), cannot bind. In the open protomer conformation (right insert), GRD can bind Ras.
