Extended Data Fig. 6: Sequence and model-based secondary structure assignment of neurofibromin isoform 2 (Nf1-23a) and neurofibromin isoform 1. | Nature

Extended Data Fig. 6: Sequence and model-based secondary structure assignment of neurofibromin isoform 2 (Nf1-23a) and neurofibromin isoform 1.

From: The structure of neurofibromin isoform 2 reveals different functional states

Extended Data Fig. 6

Regions are boxed in grey for N-HEAT and C-HEAT domains, black for L1 and L3, red for L2, light blue for GRD and gold for Sec14-PH. The 21aa insertion in isoform 2 is highlighted in yellow. Metal-coordinating residues C1032, H1558, and H1576 are labelled with arrows. Contact regions between protomer termini and between the protomer cores are highlighted green, the contacts between GRD in closed conformation and the protomer core are highlighted cyan.

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