Fig. 2: Conformational rearrangement between closed and open Nf1 states.
From: The structure of neurofibromin isoform 2 reveals different functional states
a, Comparison of closed (pink, left panels) and open (green, right panels) conformation of the Nf1 protomers. Illustrated are the massive conformational rearrangement of the GRD (light blue), its GAPex domain (magenta) and its Sec14-PH domain (yellow). b, View of both states along the principal direction of the Nf1 dimer core. c, Detail of the Zn metal binding site stabilising the closed Nf1 conformation. Superposition of open and closed state on the last three helices of GAPex illustrates the large movement of the Sec14-PH domain against the GRD/GAPex domain.
