Extended Data Fig. 4: Structure-based sequence alignment of the core domains of Nf1-23a.
From: The structure of neurofibromin isoform 2 reveals different functional states
Multiple sequence alignments of residues 1-1193 and 1850-2839 of Nf1-23a were performed in HHpred (https://toolkit.tuebingen.mpg.de/tools/hhpred) against PDB_mmCIF70_3_Mar and PDB_mmCIF30_3_Mar databases using default parameter settings with the exception of global alignment mode. The PDB codes and their corresponding chains that have aligned to Nf1-23a are shown. The amino acid sequences are coloured according to the ClustalW convention. Regions predicted to have HEAT- and ARM-repeats are indicated by rectangular boxes. The alpha-helices are highlighted by zig-zag grey lines and labelled according to Extended Data Fig. 6.
