Extended Data Fig. 5: Details of Nf1 dimer interface interactions.
From: The structure of neurofibromin isoform 2 reveals different functional states
Contact regions indicated in boxes (a-d) are detailed in the large panels. Participating protomer residues are coloured pink and yellow, respectively. Interactions are shown between a, GRD and C-HEAT/ARM core; b, c, the N-HEAT/ARM and C-HEAT/ARM core; d, the N-terminal tip of the N-HEAT/ARM domain and the C-terminal end of the C-HEAT/ARM domain. Hydrogen bonds/charged interactions are indicated by dashed lines.
