Extended Data Fig. 7: Analog screening and functional characterization of MRGPRX2 antagonists. | Nature

Extended Data Fig. 7: Analog screening and functional characterization of MRGPRX2 antagonists.

From: Structure, function and pharmacology of human itch GPCRs

Extended Data Fig. 7: Analog screening and functional characterization of MRGPRX2 antagonists.The alternative text for this image may have been generated using AI.

a, b, Dose-response curves of initial 14 analogs of ‘1592 (a) and 8 analogs of C9 (b) in the presence of EC80 concentration of (R)-ZINC-3573 using MRGPRX2 FLIPR Ca2+ assay. Data represent mean ± s.e.m. of n = 3 biological replicates. c, Dose-response curves of two potent MRGPRX2 antagonists C9 and C9-6 and an inactive compound C7 in the presence of EC80 of each MRGPRX2 peptide using MRGPRX2 FLIPR Ca2+ assay. Data represent mean ± s.e.m. of n = 3 biological replicates.

Back to article page