Extended Data Table 1 NMR and structure statistics

From: Mechanism for the activation of the anaplastic lymphoma kinase receptor

  1. Structure statistics were computed for the ensemble of 20 deposited structures of ALK (amino acids (aa) 673–1025), ALKAL2 (aa 77–152) and ALKAL1 (aa 60–129).
  2. aObservable resonances for ALK are for selective CH3 and aromatic labelling in otherwise deuterated background are included: Ala(β), Ile(δ1), Leu(δ1,2), Met(ε), Thr(γ2) and Val(γ1,2) (methyls), [1He,13Cε]-Phe and [1He,13Cε]-Tyr. For ALKAL2 and 1 13C,15N-labelled samples were used and complete side chain is reported.
  3. bCalculated for protein using the PSVS 1.5 program. Average distance constraints were calculated using the sum of r−6.
  4. cOrdered residue ranges [S(φ) + S(ψ) > 1.8] for ALK: 679–993, 996–1006, 1008–1025; ALKAL2: 78–80, 88–147; ALKAL1: 70–126.
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