Extended Data Fig. 3: Structure of prestin in high Cl− and comparison with the Intermediate.
From: The conformational cycle of prestin underlies outer-hair cell electromotility
a, Comparison between prestin (high Cl−) (blue and Red) and SLC26A9 Intermediate state (6RTF, grey). The structures are aligned based on residues 460 to 505 of one subunit (TM13-TM14, dotted box). ChimeraX was used for illustration. b, Electrostatic potential and surface charge distribution of SLC26A9 intermediate state19 compared with that of prestin in high Cl− panel c. The electrostatic charge distribution ranges from −5 to 5 kT from negative to positive charge. ChimeraX was used for illustration.
