Extended Data Fig. 7: Track parameters in the behavioral screening.
(A) Heatmap of the differentially scored behaviors among the three main behavioral groups (B1, B2 and B3). Outlined in red are the specific behaviors chosen for our screening in Fig. 3. Note that “tortuosity” is an inverse measure of “directionality”, which was used in our screening. (B) Speed and directionality obtained by epifluorescence (2D) analysis of cremasteric venules in mice with mixed chimeric bone marrow of wild-typeDsRed and non-fluorescent mutant donors, which provided internal controls for each group. Thick lines show means; The number of analyzed cells per group is shown in brackets as (control, mutant), and were obtained from at least 3 mice per group. Data analyzed by unpaired two-tailed t-test.
