Extended Data Fig. 8: T-cell dysfunction and exclusion.
From: Multi-omic machine learning predictor of breast cancer therapy response
a, Box plots showing enriched inhibitory immune cell types (Danaher gene sets) in HER2- tumours with high GGI and STAT1 (number of cases (n): pCR = 12, RD = 16). b, Box plots showing association between components of T-cell exclusion score and response (number of cases (n): pCR = 39, RD = 110). CAF: Cancer associated fibroblasts, MDSC: Myeloid-derived suppressor cells. In a, b, the box bounds the interquartile range divided by the median, with the whiskers extending to a maximum of 1.5 times the interquartile range beyond the box. Outliers are shown as dots. Two-tailed Wilcoxon rank sum tests.
