Fig. 1: Comparing sample, maternal and pregnancy characteristics for normotensive and preeclampsia groups across cohorts.
From: Early prediction of preeclampsia in pregnancy with cell-free RNA
a, Matched sample collection time both across gestation (left) and after delivery (right). b, Maternal characteristics (P = 0.02 comparing BMI in the discovery cohort). c, Matched gestational age at preeclampsia onset regardless of preeclampsia symptom severity. d, Gestational age at delivery (P = 6 × 10−7, 0.04, 8 × 10−9) for the discovery (n = 49 normotensive [37, 36, 39, 30]; n = 24 with preeclampsia [13, 17, 20, 17]), validation 1 (n = 32 normotensive [19, 27, 19, 19]; n = 7 with preeclampsia [3, 8, 6, 5]) and validation 2 (n = 61 normotensive [61]; 26 with preeclampsia [28]) cohorts. Square brackets indicate the sample number per collection group. For a, statistics were calculated by sample group. For b–d, statistics were calculated by cohort group (NS = not significant, *P < 0.05, **P ≤ 10−7; two-sided (a–c) and one-sided (d) Mann–Whitney rank test).
