Fig. 2: Before 20 weeks of gestation, cfRNA measurements segregate preeclampsia and normotensive samples and are enriched for neuromuscular, endothelial and immune cell types and tissues.
From: Early prediction of preeclampsia in pregnancy with cell-free RNA
a, Distribution of log2(FC) for DEGs (n = 544) with dashed lines at log2(FC) = ±1. b, Before 20 weeks of gestation, a subset of DEGs can separate preeclampsia (PE) and normotensive samples despite differences in symptom severity, preeclampsia onset subtype and gestational age (GA) at delivery. HIST2H2BE is also known as H2BC21. See Supplementary Table 3 for more information on genes included in heatmaps. c, Comparison of log2(FC) for DEGs between the discovery and the validation 2 cohorts reveals strong agreement. d, DEGs for preeclampsia as compared to normotensive samples can be described as either increased (orange) or decreased (dark blue) in preeclampsia over gestation. Points indicate median per trend and shaded region indicates 95% CI. e, Approximately 13% of DEGs are tissue- or cell-type-specific when compared with the Human Protein Atlas (HPA) and an augmented Tabula Sapiens (TSP+) atlas.
