Fig. 3: A subset of cfRNA changes can predict risk of preeclampsia early in gestation.
From: Early prediction of preeclampsia in pregnancy with cell-free RNA
a, Classifier performance as quantified by receiver operator characteristic curve (ROC) for samples collected in early gestation between 5 and 16 weeks, with AUROC and corresponding 90% CI noted per cohort. b, Prediction of preeclampsia incorporates cfRNA levels for 18 genes for which normalized centred log2(FC) trends hold across the discovery (n = 61 normotensive, 24 preeclampsia), validation 1 (n = 35 normotensive, 8 preeclampsia), validation 2 (n = 61 normotensive, 28 preeclampsia) and Del Vecchio (n = 17 normotensive or other complication, 5 preeclampsia) cohorts as confirmed using univariate analysis (*P ≤ 0.05, **P ≤ 0.01, ***P ≤ 0.005; one-sided Mann–Whitney rank test with Benjamini–Hochberg correction). See Supplementary Table 5 for exact P values. For box plots, centre line, box limits, whiskers and outliers represent the median, upper and lower quartiles, 1.5× interquartile range and any outliers outside that distribution, respectively. Plot limits are −8 to 4 to better visualize the main distribution. log2(CPM), log2-transformed counts per million reads.
