Extended Data Fig. 10: Therapeutic inhibition of STING reduces pathology and inflammatory gene expression after SARS-CoV-2 infection.
From: The cGAS–STING pathway drives type I IFN immunopathology in COVID-19
a, b, Mice were infected with SARS-CoV-2 infection (intranasal; 1 × 104 PFU per mouse) and intraperitoneal administration of vehicle or H-151 was started at 2 dpi. mRNA was isolated from uninfected and infected mouse lungs and relative expression of indicated genes were analysed by RT–qPCR (a). Viral burden in the lungs and brains was analysed at 6 dpi by plaque assay for infectious virus (b). c, Model of the involvement of the cGAS–STING pathway in severe SARS-CoV-2 infection created with biorender.com. Numbers are uninfected (n = 4), infected (n = 5) (a, b). Throughout the figure, bars represent mean ± s.e.m.; P values were calculated by one-way ANOVA followed by Tukey multiple comparison tests.
