Extended Data Fig. 10: 3α- and 3β-HSDH homologues and species with 3α-/ 3β-HSDH activity are likely to be positively correlated with 3-oxoLCA/ isoLCA in HMP2.
From: Human gut bacteria produce ΤΗ17-modulating bile acid metabolites
a, Differentially abundant 3α-/ 3β-HSDH homologues (FDR adjusted p-value < 0.05) with at least one significant metabolite association (Spearman correlation with FDR adjusted p-value < 0.25). Correlations were computed over a subset of paired metabolomes and metagenomes from the HMP2 cohort derived from 106 participants (CD, n = 50; UC, n = 30; Non-IBD, n = 26). b, Differentially abundant species with validated 3α-/ 3β-HSDH activity (FDR adjusted p-value < 0.05) with at least one significant metabolite association (Spearman correlation with FDR adjusted p-value < 0.25) with five metabolites are shown for the paired metabolome and metagenome samples from 106 participants (CD, n = 50; UC, n = 30; Non-IBD, n = 26) in HMP2.
