Extended Data Fig. 8: Nucleoside-related drugs are well-tolerated in air-liquid interface cultures.
From: Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2
a, Calu-3 cells were treated with the indicated concentrations of Molnupiravir (EIDD-2801) and infected with SARS-CoV-2. 48hpi viral replication was quantified by RT-qPCR and expression (viral RNA/18S) was normalized to vehicle treated cells. Data are presented as mean±SEM for n = 2-3 biological replicates. b, P-values for Fig. 3d. c, Nasal air-liquid interface cells were treated daily on the basolateral side with the indicated concentrations of drug, and at 72 h TEER, Cilia beating frequency (CBF) and toxicity (LDH) were measured. d, P-values for Fig. 4.
