Extended Data Fig. 4: Inhibitors of host nucleoside metabolism are antiviral.
From: Pyrimidine inhibitors synergize with nucleoside analogues to block SARS-CoV-2
a, Calu-3 cells were treated with the indicated IMPDH inhibitors in dose response showing infection (blue) and toxicity (green). Data are presented as mean ± SD (n = 4 independent biological replicates). b, A549-Ace2 cells were treated with the indicated inhibitors in dose response showing infection (blue) and toxicity (green). Data are presented as mean ± SD (n = 4 independent biological replicates). c, Table of the EC50, CC50 and SI for the indicated cell line and drug (uM).
