Extended Data Fig. 7: Visualizing promoter fitness landscapes in sequence space.

Visualizing the fitness landscapes for the promoters of HXT3 (a), ADH1 (b), GCN4 (c), RPL3 (d), FBA1 (e), TUB3 (f), URA3 (in defined medium) (g), URA3 (in complex medium + 5FOA) (h). 1,000 promoter sequences represented by their evolvability vectors projected onto the 2D archetypal evolvability space and coloured by their associated fitness as reflected by their predicted growth rate relative to wild type (colour, Methods), estimated by first mapping sequences to expression with our model and then expression to fitness as measured and estimated previously¹¹.