Extended Data Fig. 2: Macaque single cell RNAseq gene expression landscape.
From: The development and evolution of inhibitory neurons in primate cerebrum
a. Macaque scRNAseq UMAP colored by post conception day from which cells are sampled. b. UMAP projection colored by cell-cycle phase as classified by scanpy score_genes_cell_cycle function. c. UMAP projection colored by Leiden clusters. Although cell intrinsic differences within initial classes may predict their further subclass partitioning, the fine-grained Leiden clusters did not yield groups appearing to match terminal classes and mainly varied by neuronal differentiation trajectories. d–i. Scaled and normalized expression of d, dividing and new-born neuron marker genes e, CGE-derived neuron markers f, dLGE-derived neuron markers g, LGE-derived projection neuron markers h, MGE-derived cortical neuron markers i, MGE-derived striatal interneuron markers. An interactive browser for exploring the transcriptional features of inhibitory neuron development is available (https://dev-inhibitory-neurons.cells.ucsc.edu/)57.
