Extended Data Fig. 3: Odds ratio estimate for shet burden stratified by age group.
From: Reduced reproductive success is associated with selective constraint on human genes
Shown are odds ratio estimates for the association of shet burden with having children, stratified by participant age (y-axis) and separated into females (violet) and males (jade). Age range intervals are left-open. Dash of the line indicates whether the estimate comes from shet burden calculated from deletions (long dash), PTVs (short dash), or from a fixed effects meta-analysis (no dash). Also shown for reference are the results for all individuals regardless of age (All Ages), which is identical to the result shown in main text Fig. 1b. Asterisks indicate significance after Bonferroni correction for 20 tests (P < 2.5 × 10−3; Methods).
