Fig. 1: Cryo-EM structures of the SARS-CoV-2 Omicron S trimer.
From: Molecular basis of receptor binding and antibody neutralization of Omicron
a, Cryo-EM maps of the Omicron S-close, S-open and S-open-2 states. Protomers 1, 2 and 3 are shown in light green, royal blue and gold, respectively; this colour scheme is followed throughout. In S-open-2, the mostly disordered RBD-3 is indicated by a red dotted ellipsoid. b, Atomic model of the Omicron S-open, with mutations labelled and indicated by a red sphere. c, Side view of the overlaid protomers of the Omicron S-close. d, Top view of the overlaid RBDs of the Omicron S-close (violet red) and the G614 S-close (PDB: 7KRQ; dark grey), indicating a twist of the Omicron S-close relative to that of G614. e, Top view of the overlaid RBDs of the Omicron S-open (light green) and the G614 S-open (PDB: 7KRR; purple), indicating a twist of the Omicron S-open relative to that of G614. f, One representative 3D variability analysis motion of the Omicron S. The two left maps illustrate the top view of two extremes in the motion, with the RBD-3 indicated by a black dotted ellipsoid; the top view of the overlaid two extreme maps is shown on the right. g, Newly formed hydrogen bonds (black dashed line) in the interfaces of protomer 1–protomer 3 (blue dashed line box) and protomer 1–protomer 2 (red dashed line box) of the S-close state (see also Extended Data Fig. 2f).
