Fig. 3: Neutralization and binding activities of the mAbs against Omicron and Delta variants.
From: Molecular basis of receptor binding and antibody neutralization of Omicron
The mAbs were raised to WT RBD or S trimer proteins. a, Neutralization IC50 values and fold changes in neutralization potency for the Delta and Omicron variant pseudoviruses (PVs) compared to the WT pseudovirus. A minus sign (−) denotes decrease. The yellow highlighting indicates a more than tenfold decrease; the red highlighting denotes a more than 1,000-fold decrease. b, Neutralization of the mAbs towards WT, Delta and Omicron pseudoviruses. All mAbs were fourfold serially diluted. Data are expressed as mean ± s.e.m. of four replicate wells. The horizontal black dotted lines indicate 0% neutralization. c, Binding activities of the mAbs to recombinant S trimers of the WT, Delta and Omicron strains were tested by ELISA. Serially diluted S trimer proteins were coated onto the ELISA wells. Data are mean ± s.d. of triplicate wells. Neutralization and ELISA data are representative of two independent experiments with similar results.
