Extended Data Fig. 3: Analysis of compositional and conformational heterogeneity of the catalytic core.
From: Structure of active human telomerase with telomere shelterin protein TPP1
a, Cryo-EM 3D classification and reconstruction workflow with different masks. Insets show the FSC curves of final reconstructions. b, Superposition of H2A-H2B model and cryo-EM density. c, Local resolution evaluation of the 3.5 Å resolution reconstruction of catalytic core bond with TPP1. d, Euler angle distribution of sub-particles used for the reconstruction of catalytic core bound with TPP1. e, Model VS map FSC curve of the reconstruction with TPP1 or H2A-H2B. f, Superposition of TPP1 model and cryo-EM density.
