Extended Data Fig. 2: Formation of lacrimal-gland-like organoids from human iPS cells and ES cells.
From: Generation of 3D lacrimal gland organoids from human pluripotent stem cells
a–c, Development of lacrimal-gland-like organoids from hiPSC lines 201B7 (a) and YZWJs524 (b), and the human ES cell line, KhES-1 (c). For 201B7, n = 413; for YZWJs524, n = 6; for KhES-1, n = 40 organoids. Scale bars, 1,000 μm. d, Ratio of P3 cells in the CD200- fraction of SEAMs derived from pluripotent stem cell lines; 201B7 (n = 91 biological replicates), YZWJs524 (n = 5 biological replicates), and KhES-1 (n = 10 biological replicates). Data are presented as mean ± s.d. e, Gene expression analysis of lacrimal gland markers in lacrimal-gland-like organoids derived from pluripotent stem cell lines, 201B7 (n = 4 biological replicates), YZWJs524 (n = 5 biological replicates), and khES-1 (n = 5 biological replicates). Data are presented as mean ± s.d.
