Fig. 1: Three TMEM106B protofilament folds from human brains. | Nature

Fig. 1: Three TMEM106B protofilament folds from human brains.

From: Age-dependent formation of TMEM106B amyloid filaments in human brains

Fig. 1: Three TMEM106B protofilament folds from human brains.The alternative text for this image may have been generated using AI.

a, Amino acid sequence of TMEM106B, with residues that form β-strands in folds I, IIa, IIb and III indicated with arrows. Residue 185 is either threonine or serine. b–d, Cryo-EM density maps (in transparent grey) and atomic models for TMEM106B protofilament folds I (case 1, b), II (case 19, c) and III (case 17, d). Two alternative conformations of fold II (IIa and IIb) are indicated within dashed boxes. Residues 120–166 are shown in yellow; residues 167–210 in light blue and residues 211–254 in magenta.

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