Extended Data Fig. 5: TMEM106B filaments comprising two protofilaments.
From: Age-dependent formation of TMEM106B amyloid filaments in human brains
a. Cryo-EM micrographs with filaments comprising two protofilaments, with fold I for MSA case 18 (I-d; left), with putative fold II for MSA case 19 (II-d; middle), and with putative fold III for FTLD-TDP-C case 21 (III-d; right); α-synuclein filaments typical for MSA are also indicated (MSA). b. Cryo-EM density map and atomic model of TMEM106B filaments comprising two protofilaments of fold I. c. Three orthogional close-up views of the inter-protofilament interface.
