Extended Data Fig. 5: Survival associations.
a) Kaplan-Meier curves of disease specific survival for patients whose tumours are amplicon signature (CN4:8) attributed (orange) and non-attributed (blue). b) Cox-model hazard ratios (x-axis) for copy number signatures (y-axis) with copy number signature attribution and tumour type as a covariates (see Extended Data Fig. 5e). Horizontal bars indicate 95% confidence intervals. Sample sizes are given in Supplementary Table 5. c) Cox-model hazard ratios (x-axis) for tumour types (y-axis) with copy number signature attribution (see Extended Data Fig. 5d) and tumour type as covariates. Horizontal bars indicate 95% confidence intervals. ACC is taken as the reference tumour type (square point). d) Accelerated failure time deceleration factors (x-axis) for copy number signatures (y-axis) with copy number signature attribution and tumour type as a covariates (see Extended Data Fig. 5c). A log(deceleration factor)<1 indicates reduced survival time (accelerated failure time), while a log(deceleration factor)>1 indicates increased survival time (deaccelerated failure time). Horizontal bars indicate 95% confidence intervals. Sample sizes are given in Supplementary Table 5. e) Accelerated failure time deceleration factors (x-axis) for tumour types (y-axis) with copy number signature attribution (see Extended Data Fig. 5b) and tumour type as covariates. A log(deceleration factor)<1 indicates reduced survival time (accelerated failure time), while a log(deceleration factor)>1 indicates increased survival time (deaccelerated failure time). Horizontal bars indicate 95% confidence intervals. ACC is taken as the reference tumour type (square point). f) Kaplan-Meier curves for within-tumour type associations with copy number signature attribution. Tumour type/copy number signature combinations with a significant effect on survival (Q < 0.05) are displayed.
