Extended Data Fig. 4: Mutational burden.
From: Clonal dynamics of haematopoiesis across the human lifespan
a, Regression of number of single nucleotide variants (SNVs) in HSCs (red line) compared to HPCs (blue line). Grey shading indicates the 95% CI. The estimated difference in burden, together with the t-value is above the plot. The t-value of 1.54 demonstrates non-significance of the difference. b, Phylogenies depicted for the individuals with clonally expanded structural variants (SVs). The bar at the bottom highlights cells with one of the three classes of structural variant. The exact variant breakpoints can be found in Supplementary Table 3. c, Plot showing the percentage of HSC/MPP cells that have outlying telomere lengths per individual. Outliers were identified using the Interquartile Range criterion. There were no outliers with shorter than expected telomeres in any individuals, such that this data only reflects the percentage of cells with longer than expected telomeres. The blue line shows a regression of percentage outlying telomere lengths with age. This shows a significant negative correlation (t-value and p-value shown).
