Extended Data Fig. 5: Structural comparison between the Dicer-2–R2D2 and Dicer-2–R2D2–siRNA complexes.
From: Structure of the Dicer-2–R2D2 heterodimer bound to a small RNA duplex
(a, b) Cryo-EM structures of the Dicer-2–R2D2 heterodimer (a) and the Dicer-2–R2D2–siRNA complex (b). (c) Superimposition between Dicer-2–R2D2 (blue) and Dicer-2–R2D2–siRNA (colored as in b). The two structures were superimposed based on their RNase III domains. (d) Interaction between RBD1 and RBD2 of R2D2 in the Dicer-2–R2D2–siRNA complex. R53 of RBD1 forms a salt bridge with D144 of RBD2, stabilizing the RBD1–RBD2 interface.
