Fig. 5: Action mechanism of the Dicer-2–R2D2 heterodimer.
From: Structure of the Dicer-2–R2D2 heterodimer bound to a small RNA duplex
The structural model of the RISC-loading complex was built by manually docking the Ago2 structure (PDB: 6MFR) onto the Dicer-2–R2D2–siRNA complex. The Hsc70/Hsp90 chaperone machinery has been omitted for clarity.
