Extended Data Fig. 5: Comparison between mammalian mitochondrial and bacterial RBFA.
From: Mechanism of mitoribosomal small subunit biogenesis and preinitiation
a, RBFA in mammalian mitochondria has a mito-specific N-terminal and C-terminal extensions illustrated in the structure from this study. These mito-specfic extensions are nearly twice the size of protein and contribute to multiple functions during the ribosome assembly. Inset shows the superposition of RBFA in human mitochondria and E. coli (PDB ID: 7BOG). b, Pairwise sequence alignment of human and mouse mitochondrial RBFAs with their bacterial orthologs. The conserved amino acids are highlighted in blue. The mito-specific N and C-terminal extensions are indicated by rectangular boxes on top, and their amino acid sequences are colored in purple.
