Fig. 2: Gap in neutralizing immunity between vaccinated and unvaccinated participants infected with Omicron BA.1.
From: Omicron infection enhances Delta antibody immunity in vaccinated persons
a, Neutralization of Omicron BA.2, Beta, Delta and ancestral (with the D614G substitution) viruses compared to the Omicron BA.1 virus at the last available follow-up time point in n = 15 vaccinated or n = 24 unvaccinated participants infected with Omicron BA.1. The neutralization capacity per participant was determined in two independent experiments, and the numbers and horizontal bars are GMT FRNT50. The fold change was calculated by dividing the larger by the smaller GMT. The dashed line is the most concentrated plasma tested. The P values were determined by a two-sided Wilcoxon rank sum test; *P = 0.05–0.01; NS, not significant. The exact P values (vaccinated/unvaccinated) are: 0.22/0.087 for BA.2, 0.36/0.071 for Beta, 0.15/0.25 for Delta and 0.014/0.20 for ancestral. b, Comparison of the neutralization capacity against the Omicron BA.1, Omicron BA.2, Beta, Delta and ancestral (D614G) viruses in vaccinated (n = 15) versus unvaccinated (n = 24) participants infected with Omicron BA.1. The neutralization capacity per participant was determined in two independent experiments for all strains except for Omicron BA.1, for which six experiments were available and were used in the calculation. The points represent GMT FRNT50 per group and the error bars are GMT 95% CIs. The P values were determined by a two-sided Wilcoxon rank sum test; *P = 0.05–0.01; **P = 0.01–0.001; ***P = 0.001–0.0001. The exact P values are 0.025 (BA.1), 0.0026 (BA.2), 4.1 × 10−4 (Beta), 0.0012 (Delta) and 3.3 × 10−4 (ancestral).
