Extended Data Fig. 3: Editing ratios of nuclear DNA off-target sites identified for the three L1397N-DdCBEs. | Nature

Extended Data Fig. 3: Editing ratios of nuclear DNA off-target sites identified for the three L1397N-DdCBEs.

From: Mitochondrial base editor induces substantial nuclear off-target mutations

Extended Data Fig. 3: Editing ratios of nuclear DNA off-target sites identified for the three L1397N-DdCBEs.

a–c, Targeted deep sequencing results for selected nuclear off-target sites of ND4-L1397N (a), ND5.1-L1397N (b) and ND6-L1397N (c). For each off-target site, the editing ratio for the highest edited cytosine is plotted (blue), and the matched ratio in untreated ctrl sample is plotted in gray.

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