Extended Data Fig. 10: Chemogenetic activation of MRGPRD+ neurons evokes scratching.

Cheek model of DREADD agonist 21-evoked itch in HM3dGq fl/fl; MrgprdCreERT2+/- and -/- mice (Mann–Whitney: ***p = 0.0002; U = 0, n = 6,10 mice from 1 experiment). Error bars represent mean ± s.e.m. of n biological replicates (mice) and statistical tests are two-tailed where applicable.