Extended Data Fig. 8: Breast cancer derived CTCs lack a functional circadian clock.
From: The metastatic spread of breast cancer accelerates during sleep
a, Plot showing the expression distribution of core circadian genes in CTCs from NSG-CDX-BR16 mice. The fold change (FC, in log2 scale) and adjusted P value from the global differential expression analysis are shown for each gene. b, Density plot showing the distribution of the average expression (log2 counts per million) of genes in CTCs from NSG-CDX-BR16 mice. Core circadian genes are labeled in the X-axis. c, qPCR for Bmal1 expression in the liver, adrenal glands and primary tumor of NSG-LM2 mice (n = 3 for all the time points of the adreanal glands; n = 3 for all the time points of the liver and tumor, except ZT4 and ZT20 where n = 4). Data are relative to the time point with the lowest expression levels of Bmal1 (ZT16; set as 1) and are presented as mean ± s.e.m. n represents the number of biologically independent mice
