Extended Data Fig. 7: GATOR2 RING domains are incompatible with E2 binding.

Structural alignment between GATOR2 CTD-CTD junctions and the RNF4-UBCH5A complex (PDB ID: 4AP4)17. Individual CTD pairs are drawn (left) and superimposed with RNF4-UBCH5A (right) as follows: (a) WDR24-MIOS, (b) MIOS-WDR24, (c) MIOS-WDR59, and (d) WDR59-MIOS.