Extended Data Fig. 2: Immune phenotyping of Adar-/- Mavs-/- Zbp1Zα1α2/Zα1α2 mice.
From: ADAR1 prevents autoinflammation by suppressing spontaneous ZBP1 activation
a, Flow cytometric quantification of numbers of immune cell populations in spleens of 4 to 5 day old Adar-/- Mavs-/- mice expressing wild-type (Zbp1+/+, +/Zα1Zα2) or Zα domain mutant ZBP1 (Zbp1Zα1α2/Zα1α2). b, Representative flow plots showing the presence of neutrophils in live cell populations in spleens of mice of the indicated genotypes. c, Percentage of neutrophils in the population of live cells in spleens. d, Flow cytometry gating strategy of immune cell populations in spleens shown in (a,b). Lines in (a,c) represent the mean; each data point represents an individual mouse; the numbers of mice (n) that were analysed per genotype are indicated in the graph; P values by Mann-Whitney test
