Fig. 2: Specific somatic copy number alterations in all cancer organ-wide analysis.
From: Spatially resolved clonal copy number alterations in benign and malignant tissue
a, Genome-wide derived analysis (siCNVs) for all Visium spots harbouring tumour from prostate patient 1. Clonal groupings of spots (with approximately 10–15 cells each) were determined by hierarchical clustering. Chr., chromosome. b, Phylogenetic clone tree of the tumour clones from a, with grey clones representing unobserved, inferred common ancestors. Clone circle area is proportional to the number of spots and branch length was determined by weighted quantity of CNVs (both on a logarithmic scale). siCNV changes for each clone are available in Supplementary Table 1. c, Representation of all tissue sections from prostate patient 1. Thicker black lines denote original boundaries annotated by initial clinical pathology. d, Consensus epithelial histological annotations for sections H1_4, H1_5 and H2_5, corresponding to the right tumour focus. e, Spatial visualization of tumour clones (from a). The dashed lines mark areas where no spatial transcriptomics data were obtained owing to these regions being outside of barcoded array surfaces.
