Extended Data Fig. 3: Subgroup analysis regarding efficacy of targeted therapy on Progression free survival, in patients presenting an ESCAT I/II alteration.
From: Genomics to select treatment for patients with metastatic breast cancer
The figure reports unadjusted Hazard Ratio (diamonds) and 90% confidence intervals (error bars) estimated using a Cox proportional hazard model in each subgroup for progression or death according to clinical and biological variables. P-value for interaction between treatment arm and each variable was estimated using a Cox proportional hazard model fitted with the treatment arm, the variable and an interaction term between treatment arm and variable. All statistical tests were two sided. No adjustment was made for multiple comparisons. *: A: tyrosine kinase, B: PI3K/mTOR pathway, C: MEK pathway, D: DNA repair.
